Long rest periods between sets?

Currently with the state of things, I’m at home like most of the world and working out there. I have all the time in the world when I’m working out, and I’m curious if I can get more out of sessions with increased rest intervals between sets. I’m not in a rush, and I’m a home so I’d have a book or something, and it’s not like I’m wasting any time or losing focus.

Obviously you can usually squeeze out a few more reps if you wait an extra minute or two but is there any downside to increasing the duration between lifts? I’d assume potentially only conditioning but I’m already upping my cardio with the extra time as well.